Development and Application of Stable Isotope Internal Standard Reagents for Food Safety Testing

Abstract

This paper introduces the development and application of stable isotope internal standard reagents in the field of food safety testing. Firstly, it discusses the application progress of stable isotope technology in food authenticity identification, food safety traceability, and specific compound analysis. Secondly, it explores the use of multiple isotope internal standards in gas chromatography-mass spectrometry (GC-MS) and ultra-high pressure liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in environmental monitoring, pharmaceutical analysis, and food safety testing. The synthesis methods of stable isotope-labeled compounds and their applications in drug development, biosynthesis research, and food safety testing are analyzed. Finally, the development methods, application fields, challenges, and the importance of domestic development of deuterium-labeled isotope internal standard reagents are discussed. The paper emphasizes the significant role of stable isotope internal standard reagents in improving the accuracy and sensitivity of food safety testing and anticipates their broad application prospects in this field.